Metals Toxicity Associated with Oxidative Stress and Altered Level of Antioxidants in the Pathogenesis of Alzheimer’s Disease






Alzheimer’s Disease, Amyloid-beta, Metals toxicity, Oxidative stress, Antioxidants

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  • Jyoti Yadav Department of Forensic Medicine & Toxicology, King George’s Medical University, Lucknow, Uttar Pradesh, India.
  • Anoop K. Verma Department of Forensic Medicine & Toxicology, King George’s Medical University, Lucknow, Uttar Pradesh, India.
  • Anu Singla Dr. A.P.J. Abdul Kalam Institute of Forensic science & Criminology, Bundelkhand University, Jhansi, Uttar Pradesh, India.
  • R. K. Garg Department of Neurology, King George’s Medical University, Lucknow, Uttar Pradesh, India.


In this review, metals role in the production of oxidative stress and its association with the altered antioxidant levels have been focused in AD. We have found that metals accumulation is responsible for increased oxidative stress that induces a critical event in the pathogenesis of AD. These pathological changes might alter the antioxidant levels to attenuate free radicals in the body. Some nutritional supplement such as Vitamin E, vitamin C, and vitamin B12 may also have essential roles in the treatment of AD. Alzheimer’s disease is one of the most common forms of dementia in the elderly population. Altered levels of trace metals and heavy metals accumulation such as Iron, Copper, Zinc, Lead, Cadmium, and Mercury have been associated with oxidative stress production in Alzheimer’s disease (AD) pathogenesis. Metals accumulation is also associated with overproduced amyloid-beta may alter the level of antioxidants in AD patients.  Dietary intake of essential antioxidants has been suggested to delay or prevent cognitive impairment by many studies.   

How to Cite

Yadav, J., Verma, A. K., Singla, A., & R. K. Garg. (2023). Metals Toxicity Associated with Oxidative Stress and Altered Level of Antioxidants in the Pathogenesis of Alzheimer’s Disease. Indian Journal of Behavioural Sciences, 26(02), 138–152.


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Author Biographies

Jyoti Yadav, Department of Forensic Medicine & Toxicology, King George’s Medical University, Lucknow, Uttar Pradesh, India.


Anoop K. Verma, Department of Forensic Medicine & Toxicology, King George’s Medical University, Lucknow, Uttar Pradesh, India.



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