Intravenous Ketamine-induced Affective Switch in a Patient of Major Depressive Disorder with Suicidal Ideation: A Case Report

Published

2022-09-26

DOI:

https://doi.org/10.55229/ijbs.v25i2.14

Keywords:

Major Depressive Disorder, Suicidal ideation, Intravenous, Ketamine, Treatment-emergent affective switch

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Authors

  • Akanksha Varshney Department of Psychiatry, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
  • Shravan Kumar Department of Psychiatry, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
  • Ved Prakash Gupta Department of Psychiatry, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
  • Rehan Mateen Department of Psychiatry, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
  • Suhail Ahmad Azmi Department of Psychiatry, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Abstract

In treatment-resistant unipolar and bipolar depression, there is increasing evidence to support the fast, although the short-lived antidepressant effect of ketamine, a non-competitive glutamate N-methyl-D-aspartate receptor antagonist. Ketamine has been shown to cause transient mood elevation or euphoria, dissociative symptoms and psychotomimetic effects when administered in unipolar or bipolar depression. Still, it has not been shown to cause an affective switch resulting in persistent hypomania/mania or a manic-like state. We report the case of a 47-year-old man who developed a switch to mania while receiving a sub-anaesthetic dosage of ketamine intravenously for his third episode of recurrent, non-psychotic severe major depression with suicidal ideation. This case indicates that a polarity switch should be acknowledged as a possible side effect when using ketamine for depression.

How to Cite

Varshney, A., Kumar, S. ., Gupta, V. P. ., Mateen, R. ., & Azmi, S. A. . (2022). Intravenous Ketamine-induced Affective Switch in a Patient of Major Depressive Disorder with Suicidal Ideation: A Case Report. Indian Journal of Behavioural Sciences, 25(02), 158–160. https://doi.org/10.55229/ijbs.v25i2.14

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Author Biographies

Shravan Kumar, Department of Psychiatry, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Assistant Professor, Department of Psychiatry, JNMCH, AMU, Aligarh, India

Ved Prakash Gupta, Department of Psychiatry, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Senior Resident, Department of Psychiatry, JNMCH, AMU, Aligarh, India

Rehan Mateen, Department of Psychiatry, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Junior Resident, Department of Psychiatry, JNMCH, AMU, Aligarh, India

Suhail Ahmad Azmi, Department of Psychiatry, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Professor, Department of Psychiatry, JNMCH, AMU, Aligarh, India

 

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