Pharmacomicrobiomics: Another Contributor of Inter-Individual Variations To Drug Response
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Pharmacomicrobiomics, psychotropics, antidepressants, gut-microbiotaDimensions Badge
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Gut-brain axis is now a commonly discussed concept in a variety of clinical contexts including its well-known importance in neuropsychiatric disorders. Gut microbiota is a diverse population of microorganisms containing bacteria, yeast, protozoa, parasite, helminth, viruses, etc.Abstract
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Reference: Sender R, Fuchs S, Milo R. Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans. Cell. 2016 Jan;164(3):337–40. Weersma RK, Zhernakova A, Fu J. Interaction between drugs and the gut microbiome. Gut. 2020 Aug 1;69(8):1510-9. Kalow W, Tang B-K, Endrenyi L (1998) Hypothesis: comparisons of inter- and intra-individual variations can substitute for twin studies in drug research. Pharmacogenetics 8:283–289 Hassan R, Allali I, Agamah FE, Elsheikh SS, Thomford NE, Dandara C, Chimusa ER. Drug response in association with pharmacogenomics and pharmacomicrobiomics: towards a better personalized medicine. Briefings in Bioinformatics. 2021 Jul;22(4):bbaa292.
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